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Research

Dr. Theresa A. Guise is the Jerry W. and Peggy S. Throgmartin Professor of Oncology at the Indiana University School of Medicine. Dr. Guise's research interests encompass skeletal and muscular complications of malignancy and the effect of cancer treatment on musculoskeletal health. Specifically, she studies the molecular mechanisms by which tumor cells interact with bone cells to cause either bone destruction (osteolytic metastases) or new bone formation (osteoblastic metastases) and effects of bone metastases on skeletal muscle function.

Ongoing Research Programs

The TGF-b Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone

Development of new therapies for the treatment of bone metastases

Role of c-Met and VEGFR2 in breast cancer bone metastases

Musculoskeletal complications with sex steroid deprivation

Ryanodine receptor 1 remodeling in cancer-associated muscle dysfunction

Radiation-induced bone loss

Impact of sphingosine-1-phosphate in osteolytic bone metastasis