Hypercalcemia of malignancy: A new twist on an old problem.
Mohammad KS, Guise TA.
J Oncol Pract. 2016 May. doi: 10.1200/JOP.2016.012062.

Skeletal muscle Ca(2+) mishandling: Another effect of bone-to-muscle signaling.
Regan JN, Waning DL, Guise TA.
Semin Cell Dev Biol 2016 January. doi: 10.1016/j.semcdb.2015.11.007.

Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR.
J Clin Invest 2015 November. doi: 10.1172/JCI84937.

Excess TGF-b mediates muscle weakness associated with bone metastases in mice.
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA.
Nat Med. 2015 November. doi: 10.1038/nm.3961.

TGF-b-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
Stayrook KR, Mack JK, Cerabona D, Edwards DF, Bui HH, Niewolna M, Fournier PG, Mohammad KS, Waning DL, Guise TA.
BoneKEy Rep. 2015 July. doi: 10.1038/bonekey.2015.88.

The TGF-b Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
Fournier PG, Juarez P, Jiang G, Clines GA, Niewolna M, Kim HS, Walton HW, Peng XH, Liu Y, Mohammad KS, Wells CD, Chirgwin JM, Guise TA.
Cancer Cell. 2015 May 12. doi: 10.1016/j.ccell.2015.04.009.

Cancer-associated muscle weakness: What's bone got to do with it?
Waning DL, Guise TA.
Bonekey Rep. 2015 May. doi: 10.1038/bonekey.2015.59.

Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.
Rhodes SD, Yang H, Dong R, Menon K, He Y, Li Z, Chen S, Staser KW, Jiang L, Wu X, Yang X, Peng X, Mohammad KS, Guise TA, Xu M, Yang FC.
J Bone Miner Res. 2015 Apr 27. doi: 10.1002/jbmr.2538.

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.
Wu C, Rankin EB, Castellini L, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ.
Genes Dev. 2015 Apr 15. doi: 10.1101/gad.255000.114.

Dystrophic spinal deformities in a neurofibromatosis type 1 murine model.
Rhodes SD, Zhang W, Yang D, Yang H, Chen S, Wu X, Li X, Yang X, Mohammad KS, Guise TA, Bergner AL, Stevenson DA, Yang FC.
PLoS One. 2015 Mar. 10.1371/journal.pone.0119093.

Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks, AR.
J Clin Invest. 2015 May 1. doi: 10.1172/JCI79273.

Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model.
Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, She Y, Murthy S, Ma N, Sinex HJ, Bellido TM, Bateman TA, Mendonca MS, Mohammad KS, Guise TA.
J Bone Miner Res. 2015 Jan 15. doi: 10.1002/jbmr.2458.

The microenvironment matters: estrogen deficiency fuels cancer bone metastases.
Wright LE, Guise TA.
Clin Cancer Res. 2014 June 15. doi: 10.1158/1078-0432.CCR-14-0576.

Molecular mechanisms of bone metastasis and associated muscle weakness.
Waning DL, Guise TA.
Clin Cancer Res. 2014 June 15. doi: 10.1158/1078-0432.CCR-13-1590.

Role of TGF-? in breast cancer bone metastases.
Chiechi A, Waning DL, Stayrook KR, Buijs JT, Guise TA, Mohammad KS.
Adv Biosci Biotechnol. 2013 Oct 1. doi: 10.4236/abb.2013.410A4003.

Cancer-Associated Osteoclast Differentiation Takes a Good Look in the miR(NA)ror.
Waning DL, Mohammad KS, Guise TA.
Cancer Cell. 2013 Oct 14. doi: 10.1016/j.ccr.2013.10.001.

Breast cancer bone metastases: it's all about the neighborhood.
Guise TA.
Cell 2013 Aug 29. doi: 10.1016/j.cell.2013.08.020.

Hyperactive transforming growth factor-beta-1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.
Rhodes SD, Wu X, He Y, Chen S, Yang H, Staser KW, Wang J, Zhang P, Jiang C, Yokota H, Dong R, Peng X, Yang X, Murthy S, Azhar M, Mohammad KS, Xu M, Guise TA, Yang FC.
J Bone Miner Res. 2013 May 23. doi: 10.1002/jbmr.1992. [Epub ahead of print].

RANKL/RANK/MMP-1 molecular triad contributes to the metastatic phenotype of breast and prostate cancer cells in vitro.
Casimiro S, Mohammad KS, Pires R, Tato-Costa J, Alho I, Teixeira R, Carvalho A, Ribeiro S, Lipton A, Guise TA, Costa L.
PLoS One. 2013 May 16;8(5):e63153. doi: 10.1371/journal.pone.0063153. Print 2013.

Differential stem- and progenitor-cell trafficking by prostaglandin E2.
Hoggatt, J., Mohammad, K.S., Singh, P., Hoggatt, A.F., Chitteti, B.R., Speth, J.M., Hu, P., Poteat, B.A., Stilger, K.N., Ferraro, F., Silberstein, L., Wong, F.K., Farag, S.S., Czader, M., Milne, G.L., Breyer, R.M., Serezani, C.H., Scadden, D.T., Guise, T.A., Srour, E.F., Pelus, L.M.
Nature. (2013) Mar 21;495(7441):365-9.

Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Juarez, P., Mohammad, K.S., Yin, J.J., Fournier, P.G., McKenna, R.C., Davis, H.W., Peng, X.H., Niewolna, M., et al., Guise, T.A.
Cancer Res. (2012) Sep 20. [Epub ahead of print].

Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.
Clines, G.A., Mohammad, K.S., Grunda, J.M., Clines, K.L., et al., Guise, T.A.
J Bone Miner Res. (2011) Oct;26(10):2523-36.

Transforming Growth Factor-{beta} Receptor I Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases.
Mohammad, K.S., Javelaud, D., Fournier, P.G., Niewolna, M., et al., Guise, T.A.
Cancer Res. (2011) 71(1):175-84

Hypoxia and TGF-beta Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment.

Dunn, L.K., Mohammad, K.S., Fournier, P.G.J., McKenna, C.R., et al., Guise, T.A.
PLoS One. (2009) Sep 3;4(9):e6896.

Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation.

Clines, G.A., Mohammad, K.S., Bao, Y., Stephens, O.W., Suva, L.J., Shaughnessy, J.D. Jr, Fox, J.W., Chirgwin, J.M., Guise, T.A.
Mol Endocrinol. 21(2):486-98.

A multigenic program mediating breast cancer metastases to bone.

Kang, Y., Siegel, P.M., Shu, W.P., Drobnjak, M., Käkönen, S.M., Cordon-Cardo, C., Guise, T.A., Massagué, J.
Cancer Cell (2003). 3(6):537-549.

A causal role for endothelin-1 in the pathogenesis of osteoblastic metastases.
Yin, J.J., Mohammad, K.S., Käkönen, S.M., Harris, S., et al., Guise, T.A.
Proc Natl Acad Sci USA. (2003) 100:10549-1054.

Breast cancer cells interact with osteoblasts to support osteoclast formation.
Thomas, R.J., Guise, T.A., Yin, J.J., Elliott, J., et al.
Endocrinol. (1999) 140(10):4451-8.

TGF-beta signaling blockade inhibits parathyroid hormone-related protein secretion by breast cancer cells and bone metastases development.
Yin, J.J., Selander, K.S., Chirgwin, J.M., Dallas, M., et al., Guise, T.A.
J Clin Invest. (1999) 103(2):197.

Evidence for a causal role of parathyroid hormone-related protein in breast cancer mediated-osteolysis
Guise, T.A., Yin, J.J., Taylor, S.D., Dallas, M., et al.
J Clin Invest.(1996) 98(7):1544-1549

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